Skin

Skin, our body's initial defense, favors Vitamin E, especially Delta-Tocotrienols. These Tocotrienols are highly effective, countering skin aging by combatting oxidative stress and free radicals. The systematic review "Effects of Tocotrienol on Aging Skin" in Frontiers in Pharmacology (Oct. 2022) reports their inhibition of oxidative stress pathways. They reduce DNA damage, telomere shortening, lipid oxidation, and collagen loss, curbing pigmentation, wrinkles, dryness, and lost elasticity. Tocotrienols expedite wound healing by quelling acute inflammation, enhancing antioxidant defenses, curbing melanin, and suppressing skin cancers, including melanoma. They inhibit tyrosinase, potentially lightening the skin when applied topically. Delta-Tocotrienol offers high SPF and combats melanoma via several molecular pathways, including apoptosis induction in melanoma cells.

References

• European Journal of Science, Innovation and Technology (2021) - Anti-Aging Potentials of Tocotrienol

• International Journal of Pharmaceutics (2021) - Advancing skin delivery of α-tocopherol and γ-tocotrienol for dermatitis treatment via nanotechnology and microwave technology

• Vitamin E in Health & Disease (2021) - Vitamin E and Derivatives in Skin Health Promotion

• Scientific Reports (2018) - Targeting melanoma stem cells with the Vitamin E derivative δ-tocotrienol

• Natural Product Research (2017) - Semi-preparative HPLC purification of δ- tocotrienol (δ-T3) from Elaeis guineensis Jacq. and Bixa orellana L. and evaluation of its in vitro anticancer activity in human A375 melanoma cells

• Scientific Reports (2016) - Vitamin E δ-tocotrienol triggers endoplasmic reticulum stress- mediated apoptosis in human melanoma cells

• Handbook of Diet, Nutrition & the Skin (2012) - Dietary tocotrienol and UVB-induced skin damage

• Pigment Cell & Melanoma Research (2010) - Gamma-and-delta-tocotrienol-inhibit-skin-melanin-synthesis

• International Institute of Anticancer Research (2010) - d-δ-Tocotrienol-Mediated Cell Cycle Arrest and Apoptosis in Human Melanoma Cells