Network Antioxidants
In 1999, UC Berkeley Professor Lester Packer introduced five crucial "Network Antioxidants" that enhance each other: Glutathione, Alpha-Lipoic Acid (ALA), CoEnzyme Q10, Vitamin C, and Vitamin E. Glutathione, known as the "Master Antioxidant," is found in fruits, veggies, and meat but gets broken down during digestion. Alpha-Lipoic Acid, the "Universal Antioxidant," can boost the antioxidant network in both water and fat environments.
CoEnzyme Q10 (CoQ10) is essential for ATP production in mitochondria, but oral CoQ10 has limited cell penetration. Instead, consider taking "GeranylGeraniol" (GG) to let your body make CoQ10. Vitamin C is best in ester form, and the new Vitamin E (Tocotrienols) is a potent antioxidant, especially Delta- and Gamma-Tocotrienols, with 50-60 times the antioxidant power of Tocopherols. Tocotrienols distribute evenly in cell membranes, protecting against Free Radicals. They provide around 90% of membrane antioxidant power, making them crucial for cell and mitochondrial health.
Note: Tocotrienols are sensitive to light, heat, oxygen, metals, and extreme pH conditions. Specific guidelines for their consumption are available.
Why Do We Age?
Do you know why we get old? The universal “Free Radical Theory of Aging (FRTA)” was first published by U.C. Berkeley Prof. Denham Harman in 1956 - four years before I would arrive as a freshman and would remain for eleven years for my doctoral studies and research in Cell Physiology. FRTA is still the prevalent theory of man’s aging today. I have spent my entire professional career studying the physiology of human aging…
The Free Radical Theory of Aging (FRTA) suggests that aging results from cell damage caused by free radicals, highly reactive molecules formed when chemical bonds break. Free radicals steal electrons from neighboring molecules, causing chain reactions that harm DNA, RNA, proteins, sugars, and fats. This leads to oxidative stress, inflammation, aging, and disease.
Dr. Harman expanded the theory to include mitochondria, vital for producing ATP, our energy source. He suggested that an organism's maximum lifespan is influenced by the extent of free radical damage to cells and mitochondria. Antioxidants protect against free radicals, including "Network Antioxidants" that interact and renew each other's antioxidant capabilities.
Tocotrienols
Some Benefits of Tocotrienols are:
Powerful Antioxidant: Delta tocotrienols exhibit strong antioxidant properties, helping to neutralize harmful free radicals in the body.
Heart Health: They may support cardiovascular health by reducing cholesterol levels, improving blood vessel function, and reducing the risk of plaque buildup in arteries.
Cancer Prevention: Some studies suggest that delta tocotrienols may have anti-cancer properties, potentially inhibiting the growth of cancer cells.
Brain Health: Delta tocotrienols may support cognitive function and protect brain cells from oxidative damage, potentially reducing the risk of neurodegenerative diseases.
Geranylgeraniol
Some Benefits of Geranylgeraniol are:
Coenzyme Q10 (CoQ10) Production: Geranylgeraniol is a precursor molecule that supports the body's natural production of Coenzyme Q10, which is essential for cellular energy production.
Heart Health: CoQ10 produced from Geranylgeraniol may help improve cardiovascular health by supporting proper heart function and blood vessel health.
Antioxidant Support: Geranylgeraniol may help protect cells from oxidative damage by promoting the production of antioxidant enzymes.
Potential Cancer Prevention: There is ongoing research into Geranylgeraniol's potential role in inhibiting the growth of cancer cells, especially in certain cancer types.
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Tocotrienols as an Anti-Breast Cancer Agent (2021)
One group of natural compounds in particular, tocotrienols, has demonstrated significant potential as an anti-breast cancer agent . Known for their potent antioxidant activity, the innate anticancer properties of these unsaturated isoforms of vitamin E are often overlooked. This review will summarize current evidence and the potential of tocotrienols as an anticancer agent
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Anti-Aging Potentials of Tocotrienol (2021)
The tocotrienols have been identified as an anti-aging agent and thus implicated in improving overall quality of life by reducing the incidences of these deleterious diseases and disorders. They also protect and prevent against ultraviolet (UV)-induced skin damage and aging.
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Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols (2019)
Vitamin E is a potential candidate due to its safety. Accumulating evidence on the anti-cancer potency of vitamin E has shifted the focus from tocopherols (TOCs) to tocotrienols (TTs). γ-TT and δ-TT have the highest anti-cancer activities and target common molecular pathways involved in the inhibition of the cell cycle, the induction of apoptosis and autophagy, and the inhibition of invasion, metastasis, and angiogenesis.
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Neuroprotective and Anti-Obesity Effects of Tocotrienols (2019)
Vitamin E is a natural lipophilic vitamin, and the most famous function of vitamin E is an antioxidant activity. Because we have α-tocopherol transfer protein, many vitamin E-related reports are about α-tocopherol. Recently, other vitamin E isoforms, tocotrienols are focusing. Because tocotrienols have unique biological functions such as induction of apoptosis, neuroprotective and anti-obesity effects.
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U.S. Patent: Delta-Tocotrienol Treatment and Prevention of Pancreatic Cancer (2012)
Tocotrienols, the chemical form of vitamin E with an unsaturated isoprenoid side chain, are receiving attention as promising dietary supplements for cancer prevention and treatment.
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U.S. Patent: Delta Tocotrienol As A Radioprotective Countermeasure Agent (2009)
A method for treating the effects of radiation in a subject, comprising administering to the subject a composition comprising a radioprotective amount of delta-tocotrienol or a derivative thereof.