Cholesterol
Delta-Tocotrienols naturally lower Total Cholesterol and LDL Cholesterol by inhibiting the hepatic enzyme responsible for cholesterol production. They also impede LDL Cholesterol oxidation, a crucial early step in atherosclerotic plaque formation. Furthermore, Delta-Tocotrienols inhibit cytokines like TNF-alpha, IL-2, IL-4, IL-6, and IL-8, widely recognized markers associated with Cardiovascular Disease.
Many Americans turn to Statin drugs for cholesterol reduction and Bisphosphonate drugs for osteoporosis management. Regrettably, these drugs often lead to muscle weakness and energy depletion due to their impact on CoEnzyme Q10 (CoQ10), a vital essential nutrient necessary for mitochondrial energy production. Statin side effects include muscle pain, dysfunction, increased inflammation, cognitive issues, and liver toxicity. Research shows that Tocotrienols can ameliorate lipid markers and profiles, with a university study pinpointing 250 mg of Delta-Tocotrienol per day as the optimal dose to maintain healthy lipid levels within four weeks of daily use.
Moreover, a newly recognized essential nutrient, Geranylgeraniol (GG), derived from the Annatto plant, remarkably mitigates negative side effects associated with both Statin and Bisphosphonate drugs. Statins are known to deplete CoQ10 and GG, adversely affecting cellular and mitochondrial functions, resulting in energy loss and muscle weakness. A recommended daily dosage of 150mg of GG serves as an effective "Cholesterol Companion," especially for elderly individuals, to counter these detrimental changes.
References
Journal of the Australian Traditional-Medicine Society (2019) - Vitamin E Tocotrienols: The next generation antioxidant and anti-inflammatory nutrient
Journal of Agriculture and Food Chemistry (2016) - α-Tocopherol Attenuates the Triglyceride- and Cholesterol-Lowering Effects of Rice Bran Tocotrienol in Rats Fed a Western Diet
International Journal of Molecular Science (2016) - Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer’s Disease
Nutrition & Metabolism (2011) - Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study
Atherosclerosis (2002) - Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans
Lipids (1995) - Response of hypercholesterolemic subjects to administration of tocotrienols
The American Journal of Clinical Nutrition (1991) - Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols